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2 edition of Effects of long term electrical stimulation on protein synthesis in mammalian skeletal muscle. found in the catalog.

Effects of long term electrical stimulation on protein synthesis in mammalian skeletal muscle.

Bernadette McGurk

Effects of long term electrical stimulation on protein synthesis in mammalian skeletal muscle.

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Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (B.Sc.) - University of Birmingham, Dept of Anatomy, 1982.

ID Numbers
Open LibraryOL13802547M

protein synthesis in skeletal muscle is stimulated by either increased availability of amino acids, particularly the branched-chain amino acid leucine, or by resistance exercise. The protein synthetic response to both effectors is due in part to stimulation of the initiation of mRNA translation. We recently reported that electrical stimulation-induced resistance exercise also affects levels of proteins involved in mitochondrial dynamics in rat skeletal muscle. There is growing evidence that calorie restriction (CR) can extend the life span of many species (9, 13), and its beneficial effects on mitochondrial function are widely.   Sarcopenia, the loss of skeletal muscle mass during aging, increases the risk for falls and dependency. Resistance exercise (RE) training is an effective treatment to improve muscle mass and strength in older adults, but aging is associated with a smaller amount of training-induced hypertrophy. This may be due in part to an inability to stimulate muscle-protein synthesis (MPS) Cited by:   The purpose of this review was to determine whether past research provides conclusive evidence about the effects of type and timing of ingestion of specific sources of protein by those engaged in resistance weight training. Two essential, nutrition-related, tenets need to be followed by weightlifters to maximize muscle hypertrophy: the consumption of g -1 of body .

Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women Clinical Nutrition Whey protein supplementation in association with resistance training on additional muscle strength gain in Cited by:


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Effects of long term electrical stimulation on protein synthesis in mammalian skeletal muscle. by Bernadette McGurk Download PDF EPUB FB2

The effects of chronic electrical stimulation on Effects of long term electrical stimulation on protein synthesis in mammalian skeletal muscle. book fiber phenotype and metabolism are well known, but its impact on the extracellular matrix is poorly understood.

Material pro-perties of skeletal muscle are largely influenced by the viscoelastic properties of. Electrical muscle stimulation group I included 8 men and 1 woman with a mean ± SD age of ± years. Next, we analyzed the changes in lower limb muscles of the 5 patients whom we could evaluate for the full 6 weeks (EMS group II).

Electrical muscle stimulation group II included 4 men and 1 woman with a mean ± SD age of ± by: Abstract—Electrical Muscle Stimulation (EMS) has been the previous generations long before.

In those days EMS, preparing was predominantly utilized as a part of treatment for result effects on skeletal muscle mass, upper body muscle mass, lower body muscle mass, dominant hand muscle.

The muscle mass, or CSA of the individual fibers, is maintained when protein synthesis and muscle protein degradation is in equilibrium. A disturbance in this balance will lead to either muscle hypertrophy Effects of long term electrical stimulation on protein synthesis in mammalian skeletal muscle.

book muscle atrophy (Tang et al., ; Kumar et al., ). Since one of the main the purposes of resistance training frequently is to Cited by: Effects of Electrical Muscle Stimulation on Body Composition, Muscle Strength, and Physical Appearance June The Journal of Strength and Conditioning Research 16(2)   The efficacy of electrical stimulation on a chronically denervated muscle depends on stimulus parameters, which have an important influence on the development of atrophy.

Stimulus frequency and/or total activity are particularly responsible for the development of some histological, biochemical and contractile features.

The present study in 18 rabbits deals with a recently developed electrical Cited by: A trophic protein purified from chicken sciatic nerves, sciatin, was added to postmitotic myotube cultures of chicken embryonic skeletal muscle to determine sciatin's effect on protein turnover.

At a concentration of 20 to 25 μg/culture dish, sciatin selectively stimulated the rate of incorporation of [14 C]leucine into muscle protein by as much as 36% without affecting the rate of protein Cited by:   Effects on fast and slow patterns of tonic long-term stimulation on contractile properties of fast muscle in the cat.

J Physiol (Lond) ; 73– CASCited by: Effects of electrical stimulation-induced leg training on skeletal muscle adaptability in spinal cord injury Article in Scandinavian Journal of Medicine and Science in Sports 12(5) The assessment of the acute effects of exercise reveals important information on the specific control of protein synthesis in skeletal muscle.

Firstly, it is striking that protein synthesis is depressed during intense exercise before it rises again during the recovery phase from a workout (31, 42). Neuromuscular electrical stimulation (NMES), a technique that consists of generating visible Effects of long term electrical stimulation on protein synthesis in mammalian skeletal muscle.

book contractions with portable devices connected to surface electrodes, has been shown to be effective in treating impaired muscles as it has the potential to preserve muscle-protein synthesis and prevent muscle atrophy during prolonged periods of by:   Ramirez BU, Pette D () Effects of long-term electrical stimulation on sarcoplasmic reticulum of fast rabbit muscle.

FEBS Lett – CrossRef PubMed Google Scholar Reichmann H, Nix A () Changes of energy metabolism, myosin light chain composition, lactate dehydrogenase isozyme pattern and fibre type distribution of denervated fast Cited by: The Lancet PREVENTION OF DISUSE MUSCLE ATROPHY BY MEANS OF ELECTRICAL STIMULATION: MAINTENANCE OF PROTEIN SYNTHESIS J.N.A.

Gibson K. Smith M.J. Rennie Department of Orthopaedic Surgery, University of Edinburgh, and Department of Physiology, University of Dundee, United Kingdom The effect of percutaneous electrical stimulation in preventing immobilisation-induced muscle Cited by:   acute and chronic alcohol intoxication decreases rates of skeletal muscle protein synthesis predominately in type II muscle fibers at least in part through impairment of mammalian target of rapamycin (mTOR)-dependent translation initiation (27, 29–31, 49).

mTOR is a serine/threonine (Ser/Thr) kinase that exists in two distinct protein complexes, mTORC1 and by: In our study, electrical stimulation increased specific force of human myobundles by 2-fold (Fig.

5E) yielding the highest specific force reported for human engineered muscle ( ± mN/mm 2), but still significantly lower than those of native human skeletal muscles (–mN/mm 2) [21,68].Cited by: Therefore, the possibility that estrogen may play an inhibitory role in the development of skeletal muscle fibers has to be considered.

Academic Press, Inc. INTRODUCTION Skeletal muscles of the mammalian male are larger than those of the female and numerous studies of the effects of androgens on skeletal muscle have been by: Background: In skeletal muscle, the nutrient-induced stimulation of protein synthesis requires signaling through the mechanistic target of rapamycin complex 1 (mTORC1).

Expression of the repressor of mTORC1 signaling, regulated in development and DNA damage 1 (REDD1), is elevated in muscle during various atrophic conditions and diminished under hypertrophic by: Effects of Electrical Stimulation Parameters on Fatigue in Skeletal Muscle N euromuscular electrical stimulation (NMES) is a promising tool in the rehabilitation of individuals with a limited ability to activate their skeletal muscles,13,35,36 as well as a method of strength training and short-term.

McGurk B, Salmons S () Effects of long term electrical stimulation on protein synthesis in skeletal muscle. Fifth Int Cong Neuromusc Diseases, Marseilles, France TH 63 Mastri C, Salmons S, Thomas GH () Early events in the response of fast skeletal muscle to chronic low-frequency by: In general, comfort and pain have been used to define limits which are assumed to be equally applicable to involved persons.

Initial studies have been directed to determine the nature of electrical signals which produce the maximum stimulation effects with minimum discomfort and pain. Constant current stimulation was chosen as an optimum by: TECHNICAL APPROACHES TO HUMAN MUSCLE PROTEIN TURNOVER.

Sincewhen human myofibrillar and sarcoplasmic protein synthesis were first measured (), advances in techniques have led to a set of methods that are able to reliably measure the effects of physiological changes to MPS over times as short as 1 ements in the sensitivity and precision of gas chromatography mass Cited by:   Negative energy balance and dietary protein intake: effects on FFM, nitrogen balance, and protein turnover.

Energy balance and dietary protein intake are critical factors that contribute to the regulation of skeletal muscle mass by influencing whole-body and skeletal muscle protein metabolism (8–10).In a recent systematic review of publications from toWeinheimer et al.

reported Cited by: Functional electric stimulation can induce skeletal muscle changes, such as a shift to a fast-twitch MHC phenotype in SCI [94–95]. Transcranial electrical nerve stimulation can improve H reflex response and reduce spasticity after stroke and, in combination with task-related training, improve walking function [46,96].

Finally, pharmaceutical agents can also target skeletal by:   It is known that long-term treatment of rats with the drug causes myopathy and decreased skeletal muscle protein concentration (20,21). These findings suggest that muscle protein synthesis may be inhibited by chronic activation of the BCKDH complex, thereby promoting BCAA oxidation.

Therefore, the low activity of the BCKDH complex in the Cited by: Adaptation of Mammalian Skeletal Muscle Fibers to Chronic Electrical Stimulation Article Literature Review (PDF Available) in Reviews of Physiology, Biochemistry and Pharmacology   Electrical impulses are necessary for proper in vivo skeletal muscle development.

To fabricate functional skeletal muscle tissues in vitro, recapitulation of the in vivo niche, including physical Cited by:   Abstract. Some effects of the sea anemone toxin, ATX-II, on vertebrate skeletal muscle have been described. At a concentration of 1 X 10(-7)-1 X 10(-6)M, ATX-II caused a sodium-dependent depolarization of the muscle fibres of the rat soleus and extensor digitorum longus, of the mouse soleus and extensor digitorum longus and of the chicken posterior latissimus dorsi.

In this study, effects of protein and carbohydrate on skeletal muscle regeneration, given either by shake or by a meal, were compared. 35 subjects performed a 10 km run. The order of concurrent endurance and resistance exercise modifies mTOR signaling and protein synthesis in rat skeletal muscle Riki Ogasawara,1,2 Koji.

() Gondin J, Cozzone PJ, Bendahan D. Is high-frequency neuromuscular electrical stimulation a suitable tool for muscle performance improvement in both healthy humans and athletes. Eur J Appl Physiol. ; (10) () Gorgey AS, Black CD, Elder CP, Dudley GA.

Effects of electrical stimulation parameters on fatigue in skeletal muscle. However, a complete meal containing protein (or leucine alone) produced complete recovery of muscle protein synthesis within the first hour after exhaustive exercise. It is now clear that leucine stimulates muscle protein synthesis through the protein kinase mammalian target of rapamycin (mTOR) activating initiation factors eIF4E and rpS6 (2,20).Cited by:   To investigate the effects of dietary crude protein (CP) restriction on muscle fiber characteristics and key regulators related to protein deposition in skeletal muscle, a total of 18 growing-finishing pigs ( ± kg) were allotted to 3 groups and fed with the recommended adequate protein (AP, 16 % CP) diet, moderately restricted protein (MP, 13 % CP) diet and low protein (LP, Cited by:   Abstract.

Background: In skeletal muscle, the nutrient-induced stimulation of protein synthesis requires signaling through the mechanistic target of rapamycin complex 1 (mTORC1). Expression of the repressor of mTORC1 signaling, regulated in development and DNA damage 1 (REDD1), is elevated in muscle during various atrophic conditions and diminished under hypertrophic Cited by: two of the most potent stimulators of skeletal muscle protein synthesis (MPS) are feeding and resistance exercise ().The postprandial increase in circulating essential amino acids stimulates a marked rise in protein synthesis (7, 15, 35); this effect appears to be due to the amino acids themselves acting as the stimulus and not an effect due to the modest increases in insulin that result from Cited by:   Abstract Muscle protein synthesis (MPS) is the driving force behind adaptive responses to exercise and represents a widely adopted proxy for gauging chronic efficacy of acute interventions, (i.e.

exercise/nutrition). Recent findings in this arena have been progressive. Nutrient‐driven increases in MPS are of finite duration (∼ h), switching off thereafter despite sustained amino acid Cited by:   Regardless of age or gender, resistance training or provision of adequate amounts of dietary protein (PRO) or essential amino acids (EAA) can increase muscle protein synthesis (MPS) in healthy adults.

Combined PRO or EAA ingestion proximal to resistance training, however, can augment the post-exercise MPS response and has been shown to elicit a greater anabolic effect than exercise.

Note that despite the increase in microRNA‐1 levels, the PI3K‐AKT pathway is increased, which seems to be associated with a reduction in PTEN levels. In addition, HDAC4 levels decrease, which leads to an increase in follistatin, MEF2C, and MyoD levels. These changes improve protein synthesis, skeletal muscle differentiation, and myocyte : Ligia M.

Antunes‐Correa, Ligia M. Antunes‐Correa, Patricia F. Trevizan, Aline V.N. Bacurau, Larissa. Aerobic exercise can produce skeletal muscle adaptations that protect myocytes and muscle fibers from muscle injury, improve muscle performance, and delay muscle fatigue [27,].

To our knowledge, the effects of exercise on muscle structure and function have never been systematically studied after stroke. muscle protein metabolism alternates between periods of net catabolism in the postabsorptive state and net anabolism in the postprandial states, with the latter being primarily a result of changes in muscle protein synthesis ().Ingestion of a protein-deficient meal does not stimulate muscle protein synthesis (), because the availability of blood amino acids is not by: Previous studies have demonstrated that using electrical stimulation to replicate RE accurately stimulates mTORC1 signaling and skeletal muscle protein synthesis, and long‐term training can induce muscle hypertrophy (Kido et al.

; Ogasawara et al. ).Author: Kohei Sase, Kohei Kido, Satoru Ato, Satoshi Fujita. Summary. Chronic low-frequency electrical stimulation of rabbit fast-twitch skeletal pdf induces increased levels of two intermediate filament proteins, desmin and vimentin, during the first 3 weeks of by:   The other download pdf endurance exercises such as long‐distance running or cycling that lead to skeletal muscle oxidative and metabolic capacity increase (Fan & Evans, ; Holloszy & Coyle, ).

Concurrent training is the combination of two different modes of training, which is intended to achieve both types of effects (Hickson., ). Measurements of long-term synthesis rates provide important insights into aging ebook exercise adaptations.—Robinson, M.

Ebook, Turner, S. M., Hellerstein, M. K., Hamilton, K. L., Miller, B. F. Long-term synthesis rates of skeletal muscle DNA and protein are higher during aerobic training in older humans than in sedentary young subjects but are Cited by: